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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1985-10-4
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pubmed:abstractText |
We have characterized the activation of the interleukin 1 (IL-1)-responsive T-cell lymphoma LBRM33-1A5-47 to interleukin 2 (IL-2) production by phytohemagglutinin (PHA) and IL-1. The signal provided by soluble IL-1 could be replaced by fixed P388D1 cells and the signal provided by PHA by a monoclonal antibody directed against an allotypic determinant of the Ag/MHC T-cell receptor (KJ16-133). The signal provided by fixed P388D1 does not appear to be due to alloreactivity. Instead, it appears to be due to a membrane-bound IL-1. The implications of these observations are discussed.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0008-8749
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
447-53
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:3875420-Animals,
pubmed-meshheading:3875420-Cell Line,
pubmed-meshheading:3875420-Histocompatibility Antigens Class II,
pubmed-meshheading:3875420-Humans,
pubmed-meshheading:3875420-Immune Sera,
pubmed-meshheading:3875420-Interleukin-1,
pubmed-meshheading:3875420-Lymphocyte Activation,
pubmed-meshheading:3875420-Lymphoma,
pubmed-meshheading:3875420-Macrophages,
pubmed-meshheading:3875420-Mice,
pubmed-meshheading:3875420-Rats,
pubmed-meshheading:3875420-Receptors, Antigen, T-Cell,
pubmed-meshheading:3875420-T-Lymphocytes
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pubmed:year |
1985
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pubmed:articleTitle |
Activation of an interleukin-1-responsive T-cell lymphoma by fixed P388D1 macrophages and an antibody against the Ag:MHC T-cell receptor.
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pubmed:publicationType |
Journal Article
|