| pubmed-article:3875405 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3875405 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:3875405 | lifeskim:mentions | umls-concept:C1155065 | lld:lifeskim |
| pubmed-article:3875405 | lifeskim:mentions | umls-concept:C0040845 | lld:lifeskim |
| pubmed-article:3875405 | lifeskim:mentions | umls-concept:C0279023 | lld:lifeskim |
| pubmed-article:3875405 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:3875405 | pubmed:dateCreated | 1985-9-30 | lld:pubmed |
| pubmed-article:3875405 | pubmed:abstractText | The capacity of retinoic acid to modulate human T-lymphocyte and B-lymphocyte activation by mitogens was examined. T-lymphocyte proliferation stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA) or phytohemagglutinin was enhanced by 5 nM to 5 microM retinoic acid in a dose-dependent manner with a 65 +/- 35% (SD) increase (n = 6, P less than 0.01) in TPA-stimulated proliferation induced by 5 microM retinoic acid. Retinoic acid enhanced T-lymphocyte proliferation over a wide range of background proliferation induced by different TPA concentrations. Retinoic acid alone did not stimulate T-lymphocyte proliferation. In contrast retinoic acid inhibited B-lymphocyte proliferation stimulated by TPA or phytohemagglutinin with 26.7 +/- 23.4% inhibition of TPA-stimulated proliferation induced by 5 microM retinoic acid (P less than 0.02). Retinoic acid had intermediate effects on the proliferation of different mixtures of T- and B-lymphocytes stimulated by TPA or phytohemagglutinin. The recognition that retinoic acid has opposing effects on human T- and B-lymphocyte activation by mitogens may account for the conflicting reports of the effects of retinoids on the immune response of unpurified human lymphocyte preparations. | lld:pubmed |
| pubmed-article:3875405 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3875405 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3875405 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3875405 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3875405 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3875405 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3875405 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3875405 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3875405 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3875405 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:3875405 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:3875405 | pubmed:author | pubmed-author:ValoneF HFH | lld:pubmed |
| pubmed-article:3875405 | pubmed:author | pubmed-author:PayanD GDG | lld:pubmed |
| pubmed-article:3875405 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3875405 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:3875405 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3875405 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3875405 | pubmed:pagination | 4128-31 | lld:pubmed |
| pubmed-article:3875405 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3875405 | pubmed:meshHeading | pubmed-meshheading:3875405-... | lld:pubmed |
| pubmed-article:3875405 | pubmed:meshHeading | pubmed-meshheading:3875405-... | lld:pubmed |
| pubmed-article:3875405 | pubmed:meshHeading | pubmed-meshheading:3875405-... | lld:pubmed |
| pubmed-article:3875405 | pubmed:meshHeading | pubmed-meshheading:3875405-... | lld:pubmed |
| pubmed-article:3875405 | pubmed:meshHeading | pubmed-meshheading:3875405-... | lld:pubmed |
| pubmed-article:3875405 | pubmed:meshHeading | pubmed-meshheading:3875405-... | lld:pubmed |
| pubmed-article:3875405 | pubmed:meshHeading | pubmed-meshheading:3875405-... | lld:pubmed |
| pubmed-article:3875405 | pubmed:meshHeading | pubmed-meshheading:3875405-... | lld:pubmed |
| pubmed-article:3875405 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3875405 | pubmed:articleTitle | Potentiation of mitogen-induced human T-lymphocyte activation by retinoic acid. | lld:pubmed |
| pubmed-article:3875405 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3875405 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:3875405 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3875405 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3875405 | lld:pubmed |
