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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1985-9-16
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pubmed:abstractText |
Kinetics of 7-hydroxy-methotrexate (7-OH-MTX) excretion after high-dose methotrexate (MTX) (12 g/m2) therapy were monitored in 93 consecutive drug cycles of 19 adolescent patients with osteosarcoma. A reversed-phase HPLC method was used. Serum elimination was found to be monophasic with a mean half-life of 5.5 h. Shortly after the 4-h MTX infusion period 7-OH-MTX levels exceeded those of the parent compound. By 12 h after MTX infusion 7-OH-MTX levels were 16.5 times higher than those of MTX itself. Autostimulation of MTX metabolism leading to enhanced 7-OH-MTX production after repeated drug cycles was not observed. The production of 7-OH-MTX decreased significantly from the first to the last high-dose MTX cycle of the adjuvant chemotherapy protocol.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0344-5704
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
101-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3874719-Adolescent,
pubmed-meshheading:3874719-Adult,
pubmed-meshheading:3874719-Alanine Transaminase,
pubmed-meshheading:3874719-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:3874719-Aspartate Aminotransferases,
pubmed-meshheading:3874719-Child,
pubmed-meshheading:3874719-Humans,
pubmed-meshheading:3874719-Kinetics,
pubmed-meshheading:3874719-Leucovorin,
pubmed-meshheading:3874719-Methotrexate,
pubmed-meshheading:3874719-Osteosarcoma,
pubmed-meshheading:3874719-Retrospective Studies
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pubmed:year |
1985
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pubmed:articleTitle |
Kinetics of 7-hydroxy-methotrexate after high-dose methotrexate therapy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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