Linked Life Data

3874278

Source:http://linkedlifedata.com/resource/pubmed/id/3874278

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1985-8-9
pubmed:abstractText
p-Aminobenzoic acid and p-aminosalicylic acid-N-acetyltransferase activities were determined in 105,000 X g liver cytosols from homozygous rapid acetylator (Bio. 4.24, Bio. 41.56 and Bio. 65.67) and homozygous slow acetylator (Bio. 1.5) inbred hamsters. Liver N-acetyltransferase activities were substantially higher in rapid as opposed to slow acetylator hamsters. Genetic crosses yielded F1 generation progeny with unimodal distributions of N-acetyltransferase activity intermediate between those of the rapid and slow acetylator parental strains, and F2 generation progeny with trimodal distributions (low/intermediate/high) of N-acetyltransferase activity not significantly different from a ratio of 1/2/1. Backcross matings yielded bimodal distributions of N-acetyltransferase activity in a ratio (intermediate/parental) not significantly different from 1/1. Each of these findings is consistent with simple autosomal Mendelian inheritance of two codominant alleles at a single gene locus.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
233
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
584-7
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Inheritance of liver N-acetyltransferase activity in the rapid and slow acetylator inbred hamster.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't