Linked Life Data

3873954

Source:http://linkedlifedata.com/resource/pubmed/id/3873954

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1985-8-2
pubmed:abstractText
Peritoneal macrophages harvested from rats undergoing an acute non-specific inflammatory reaction induced by an injection of calcium pyrophosphate (CaPP) into the pleural cavity released increased amounts of interleukin I (IL-I)-like material. Lymphocyte-activating factors were also found in ultrafiltrates of the macrophage supernatants below 10 kd and 5 kd. A similar pattern of activity was observed when lysates of the macrophages were tested. In addition pre-exposure of normal peritoneal macrophages to an acute pleural inflammatory exudate before supernatant production enhanced the release of lymphocyte-activating factors found both in the unfractionated supernatant and a sub-5-kd ultrafiltrate. Thus these results demonstrate that an acute inflammatory reaction, initiated by a non-antigenic stimulus is able to stimulate macrophages remote from the inflammatory site to produce a factor which behaves like IL-I in a standard IL-I assay. The presence of low-molecular-weight factors (less than 5 kd) with similar activity may suggest that degradation of IL-I has taken place to yield active fragments. Acute inflammatory exudate also augments release of these factors which may be important in the pathogenesis of inflammation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0007-1021
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
271-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Release of interleukin I and low-molecular-weight lymphocyte-activating factors by rat peritoneal macrophages and its enhancement by acute non-specific inflammatory processes.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't