rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1
|
pubmed:dateCreated |
1985-7-24
|
pubmed:abstractText |
Cross-reactive anti-DNA antibody idiotypes have been identified on tissue-bound immunoglobulins from skin biopsies of patients with systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE). Four polyclonal and two monoclonal anti-idiotypic reagents were used to screen biopsies from 24 patients with SLE, 23 patients with DLE, and 15 other patients with IgM-positive skin biopsies. Up to 46% of the SLE patients and 30% of the DLE patients were found to share idiotypes present on immunoglobulins deposited at the dermal-epidermal junction. Inhibition studies in four patients indicated that the idiotypes were on anti-DNA antibodies. In contrast, none of the anti-idiotypic antibodies bound to any of the control biopsies. These findings imply that some tissue-bound autoantibodies are derived from related families of high-frequency germ-line genes that are expressed in both SLE and DLE.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
AIM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0022-1767
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pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
135
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
261-4
|
pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:3873490-Antibodies, Antinuclear,
pubmed-meshheading:3873490-Antibodies, Monoclonal,
pubmed-meshheading:3873490-Binding Sites, Antibody,
pubmed-meshheading:3873490-Cross Reactions,
pubmed-meshheading:3873490-DNA,
pubmed-meshheading:3873490-Humans,
pubmed-meshheading:3873490-Immunoglobulin G,
pubmed-meshheading:3873490-Immunoglobulin Idiotypes,
pubmed-meshheading:3873490-Immunoglobulin M,
pubmed-meshheading:3873490-Lupus Erythematosus, Discoid,
pubmed-meshheading:3873490-Lupus Erythematosus, Systemic,
pubmed-meshheading:3873490-Skin
|
pubmed:year |
1985
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pubmed:articleTitle |
Detection of cross reactive anti-DNA antibody idiotypes on tissue-bound immunoglobulins from skin biopsies of lupus patients.
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pubmed:publicationType |
Journal Article
|