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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1985-5-31
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pubmed:abstractText |
Interleukin-1 (IL-1) is a monocyte derived factor that participates in immune regulation and in the regulation of fibroblast proliferation and collagen deposition. It therefore, seems particularly pertinent to study in scleroderma, a disorder of immune regulation where increased collagen deposition is a hallmark. The production of IL-1 by lipopolysaccharide stimulated monocytes from 18 untreated scleroderma patients was akin to that of their normal matched controls. However, the unstimulated monocytes from six of the 18 scleroderma patients released IL-1 activity spontaneously into their supernatants. All six patients with spontaneous IL-1 release had less than 5 years disease duration. The response to IL-1 by T lymphocytes from patients with scleroderma was low as compared to those from controls. The presence of spontaneous IL-1 production with decreased response to IL-1 in scleroderma may indicate an in vivo pre-activation of monocytes to produce this factor that might have a bearing in the pathogenesis of collagen deposition in scleroderma.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3872755-316754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3872755-4587740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3872755-479763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3872755-6264478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3872755-6451199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3872755-6453999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3872755-6460819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3872755-6607312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3872755-6770028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3872755-6774815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3872755-6788417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3872755-6800841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3872755-6979554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3872755-7402294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3872755-80435
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
666-72
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3872755-Adult,
pubmed-meshheading:3872755-Cell Division,
pubmed-meshheading:3872755-Female,
pubmed-meshheading:3872755-Humans,
pubmed-meshheading:3872755-Indomethacin,
pubmed-meshheading:3872755-Interleukin-1,
pubmed-meshheading:3872755-Middle Aged,
pubmed-meshheading:3872755-Monocytes,
pubmed-meshheading:3872755-Rosette Formation,
pubmed-meshheading:3872755-Scleroderma, Systemic,
pubmed-meshheading:3872755-T-Lymphocytes
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pubmed:year |
1985
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pubmed:articleTitle |
Spontaneous production of, and defective response to, interleukin-1 by peripheral blood mononuclear cells from patients with scleroderma.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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