Linked Life Data

3871421

Source:http://linkedlifedata.com/resource/pubmed/id/3871421

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1985-3-19
pubmed:abstractText
The in vitro response to Con A of lymphocytes from iron-deficient and normal mice in media containing either 10% fetal calf serum, apotransferrin or 20% iron-saturated transferrin was similar for the iron-deficient and control groups. However, the degree of proliferation in serum-free medium containing apotransferrin was significantly lower in all groups, compared to the responses in media containing either 20% iron-saturated transferrin or 10% fetal calf serum. Proliferation of lymphocytes from normal, iron-deficient or iron-repleted mice was lower in media supplemented with serum from iron-deficient mice than when serum from normal or iron-repleted mice was used. Addition of sufficient iron to bring the iron level of the deficient serum to that of normal serum significantly improved its ability to promote proliferation, while in vivo repletion of iron-deficient mice resulted in a restoration of normal lymphocyte responses to Con A. The proportion of cells positive for Thy 1.2, Ly 1 and Ly 2 antigens did not differ significantly between any groups of mice. Protein synthesis by cells proliferating in serum-free medium containing apotransferrin or 20% iron-saturated transferrin was the same in all groups of mice. These results indicate that decreased lymphocyte proliferative responses in iron deficiency may be due to inadequate levels of circulating transferrin-bound iron, rather than to intrinsic defects in the cells themselves or changes in the proportions of different T-cell subsets, and that iron availability does not affect protein synthesis by proliferating lymphocytes.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3871421-1008077, http://linkedlifedata.com/resource/pubmed/commentcorrection/3871421-1089127, http://linkedlifedata.com/resource/pubmed/commentcorrection/3871421-1109157, http://linkedlifedata.com/resource/pubmed/commentcorrection/3871421-1127523, http://linkedlifedata.com/resource/pubmed/commentcorrection/3871421-1127529, http://linkedlifedata.com/resource/pubmed/commentcorrection/3871421-4117379, http://linkedlifedata.com/resource/pubmed/commentcorrection/3871421-4375687, http://linkedlifedata.com/resource/pubmed/commentcorrection/3871421-549778, http://linkedlifedata.com/resource/pubmed/commentcorrection/3871421-710971, http://linkedlifedata.com/resource/pubmed/commentcorrection/3871421-7141718, http://linkedlifedata.com/resource/pubmed/commentcorrection/3871421-7251059, http://linkedlifedata.com/resource/pubmed/commentcorrection/3871421-759049
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0019-2805
pubmed:author
pubmed:issnType
Print
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
325-32
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Effect of iron deficiency on the response of mouse lymphocytes to concanavalin A: the importance of transferrin-bound iron.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't