Linked Life Data

3870533

Source:http://linkedlifedata.com/resource/pubmed/id/3870533

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1987-11-20
pubmed:abstractText
This work deals with the effect of thiazolidine-4-carboxylic acid (thioproline) upon several in vitro established human cell lines. Times-lapse microcinematography is used to study the action of thioproline on HeLa cells, employing high doses during a short time, and continuous exposure to medium and small doses. The effect of thioproline in mixed cultures of HeLa cells and human lymphoblasts is described. Special attention is paid to the observed cell cycle phase specificity, and to the phenomenon described as reverse transformation that has been associated to the drug. Marked differences is the sensitivity to thioproline are observed for the different types of in vitro established cell lines. The effect is always produced during the G1 and S phases of the cell cycle. Cell changes are produced only after contacting with one another, and the biochemical reactions which are proper of cell contact inhibition of growth and/or genotypic reverse transformation were never observed, so that the mechanism of action of the drug has to be revised. From a morphodynamic point of view, thioproline is an interesting drug because it produces peculiar effects which differ markedly from those produced by the other cancer chemotherapy agents. Thioproline could prove to be useful for cancer chemotherapy if used in combination with other drugs, knowing that it is a low activity phase specific antineoplastic drug and not a drug producing reverse transformation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0482-640X
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
383-410
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Time-lapse microcinematography of the effect of thiazolidine carboxylic acid (thioproline) upon tissue cultures.
pubmed:affiliation
Departament of Biology and Biochemistry of Cancer, Instituto Nacional de Oncología, Madrid.
pubmed:publicationType
Journal Article