Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1986-1-29
|
| pubmed:abstractText |
High level of tyrosine protein kinase activity was found in a membrane fraction isolated from an acute myeloblastic leukemia, out of 24 leukemias of different origin investigated. The major substrate for tyrosine phosphorylation in vitro was a 58 kDA protein (p58). The phosphorylation proceeded actively at 0 degrees C and was strongly stimulated by Mn2+ ions. Comparison by partial proteolysis of the p58 with similar phosphoproteins from a T-lymphoma line (KE37) and from lectin stimulated lymphocytes showed high similarity. The possible role of the tyrosine kinase activity in this leukemia is discussed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0145-2126
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1345-51
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:3866116-Gastrins,
pubmed-meshheading:3866116-Humans,
pubmed-meshheading:3866116-Leukemia, Myeloid, Acute,
pubmed-meshheading:3866116-Phosphoproteins,
pubmed-meshheading:3866116-Phosphorylation,
pubmed-meshheading:3866116-Protein-Tyrosine Kinases,
pubmed-meshheading:3866116-Tyrosine
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Acute myeloblastic leukemia with active tyrosine protein kinase.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|