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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
1985-11-18
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pubmed:abstractText |
The localization of MC25, an antigen first detected on the surface of human neuroblastoma cells, was determined in cultured cells and tissues. Neuroblastoma cell lines (15/17) express the antigen on the surface and in the cytoplasm (scMC25+), whereas 156/160 cell lines derived from other normal and malignant human cell types are scMC25-. However, MC25 is found in the nucleus of scMC25- cells (nMC25+), presenting a discrete granular pattern. In scMC25+/nMC25- neuroblastoma lines, apparent antigen shifting from the cell surface/cytoplasm to the nucleus accompanies variant formation, which represents a transition in the neuronal differentiation program of these cells. Results of immunohistochemical studies with human tissues parallel the findings with cultured cells. Almost all cell types are scMC25-/nMC25+; basal cells of the epidermis are the only cells constitutively expressing cMC25; and a population of neurons are the only scMC25-/nMC25- cells. Alternative localization of MC25 to different cellular compartments and antigen shifting are reminiscent of the behavior of certain developmentally regulated antigens in Drosophila and Xenopus.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3863134-14392240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3863134-2578310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3863134-3968181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3863134-4748425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3863134-5414889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3863134-5624979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3863134-6086146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3863134-6088992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3863134-6125265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3863134-6137586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3863134-6166661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3863134-6186395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3863134-62055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3863134-6428951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3863134-6616438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3863134-6653879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3863134-6814762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3863134-6825097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3863134-6863944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3863134-6934537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3863134-6978341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3863134-7037175
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6894-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3863134-Antibodies, Monoclonal,
pubmed-meshheading:3863134-Antigens,
pubmed-meshheading:3863134-Antigens, Neoplasm,
pubmed-meshheading:3863134-Antigens, Nuclear,
pubmed-meshheading:3863134-Antigens, Surface,
pubmed-meshheading:3863134-Cell Line,
pubmed-meshheading:3863134-Cell Nucleus,
pubmed-meshheading:3863134-Humans,
pubmed-meshheading:3863134-Neuroblastoma,
pubmed-meshheading:3863134-Nucleoproteins
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pubmed:year |
1985
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pubmed:articleTitle |
Cell surface antigen of human neuroblastomas is related to nuclear antigen of normal cells.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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