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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
1985-10-7
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pubmed:abstractText |
DNA structural analysis of the Qa region in two BALB/c mouse substrains with different Qa-2 phenotypes reveals that a deletion of DNA has occurred in BALB/cBy (Qa-2-) mice relative to BALB/c (Qa-2+) mice. We propose that this deletion arises from unequal crossing-over and recombination between adjacent BALB/c class I genes and results in the generation of a hybrid class I gene in BALB/cBy mice. Furthermore, we suggest that this is a direct cause of the change in Qa-2 phenotype. Further support for this model was obtained from transfection experiments in which cloned genes from the equivalent part of the Qa region in C57BL/10 mice were introduced into L cells. Four C57BL/10 genes, arranged in two almost identical pairs, encode polypeptides that are precipitated from lysates of transfectants with anti-Qa-2/3 antiserum. Although loss of one pair of these genes in BALB/c mice has no qualitative effect on Qa-2 phenotype, the loss of both pairs of genes via gene fusion leads to the loss of the Qa-2+ phenotype in BALB/cBy mice.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862106-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862106-194704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862106-236308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862106-2983348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862106-6088985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862106-6152713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862106-6173317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862106-6280871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862106-6673205,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862106-6815535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862106-6895187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862106-6979571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862106-90552
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5920-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3862106-Animals,
pubmed-meshheading:3862106-Antigens, Surface,
pubmed-meshheading:3862106-Chromosome Deletion,
pubmed-meshheading:3862106-Cloning, Molecular,
pubmed-meshheading:3862106-Gene Expression Regulation,
pubmed-meshheading:3862106-Genes,
pubmed-meshheading:3862106-Histocompatibility Antigens Class I,
pubmed-meshheading:3862106-L Cells (Cell Line),
pubmed-meshheading:3862106-Major Histocompatibility Complex,
pubmed-meshheading:3862106-Membrane Proteins,
pubmed-meshheading:3862106-Mice,
pubmed-meshheading:3862106-Mice, Inbred BALB C,
pubmed-meshheading:3862106-Plasmids,
pubmed-meshheading:3862106-Transfection
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pubmed:year |
1985
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pubmed:articleTitle |
Structure and expression of genes encoding murine Qa-2 class I antigens.
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pubmed:publicationType |
Journal Article
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