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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
1985-10-21
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pubmed:abstractText |
The human immunoglobulin V lambda locus has been studied in relation to chromosomal translocations involving chromosome 22. DNA probes for two V lambda genes which belong to different subgroups and do not cross hybridize, were used to show that both V lambda genes are located on the Philadelphia chromosome in chronic myeloid leukaemia (CML). Both genes map in band 22q11 to a region that is bounded on the distal side by the breakpoints for CML 9:22 translocations and on the proximal side by the breakpoint for an X:22 translocation. We have found no evidence for rearrangements or amplification of either V lambda gene in CML, in either the chronic or acute phases of the disease. In K562 cells which are derived from the pleural effusion of a patient with Ph1-positive CML, there appears to be no rearrangement of the V lambda genes, but they are both amplified about four times. We have estimated that the minimum size for the amplification unit in K562 cells is 186 kb.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862074-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862074-163658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862074-2578837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862074-301573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862074-3923432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862074-3923440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862074-4126434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862074-4200179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862074-6091030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862074-6095199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862074-6273747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862074-6291150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862074-6306134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862074-6308652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862074-6316147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862074-6319012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862074-6402758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862074-6433113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862074-6436636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862074-6574514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862074-6580644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862074-6582938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862074-6795508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862074-6944169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862074-6948415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862074-6960256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862074-7079737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862074-7192199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3862074-881736
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0305-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5761-70
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3862074-Animals,
pubmed-meshheading:3862074-Cell Line,
pubmed-meshheading:3862074-Chromosome Mapping,
pubmed-meshheading:3862074-Chromosomes, Human, 21-22 and Y,
pubmed-meshheading:3862074-Cricetinae,
pubmed-meshheading:3862074-DNA,
pubmed-meshheading:3862074-Genes,
pubmed-meshheading:3862074-Genotype,
pubmed-meshheading:3862074-Humans,
pubmed-meshheading:3862074-Hybrid Cells,
pubmed-meshheading:3862074-Immunoglobulin Variable Region,
pubmed-meshheading:3862074-Leukemia, Myeloid,
pubmed-meshheading:3862074-Nucleic Acid Hybridization,
pubmed-meshheading:3862074-Reference Values,
pubmed-meshheading:3862074-Translocation, Genetic
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pubmed:year |
1985
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pubmed:articleTitle |
Regional mapping of two human immunoglobulin V lambda genes and analysis of the V lambda locus in chronic myeloid leukaemia.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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