Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4715
|
| pubmed:dateCreated |
1985-9-11
|
| pubmed:abstractText |
The human c-mos proto-oncogene is located on chromosome 8 at band q22, close to the breakpoint in the t(8;21) (q22;q22) chromosome rearrangement. This translocation is associated with acute myeloblastic leukemia, subgroup M2. The c-myc gene, another proto-oncogene, has been mapped to 8q24. The breakpoint at 8q22 separates these genes, as determined by in situ hybridization of c-mos and c-myc probes. The c-mos gene remains on the 8q-chromosome and the c-myc gene is translocated to the 21q+ chromosome. Southern blot analysis of DNA from bone marrow cells of four patients with this translocation showed no rearrangement of c-mos.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0036-8075
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
23
|
| pubmed:volume |
229
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
767-9
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3860954-Chromosome Mapping,
pubmed-meshheading:3860954-Chromosomes, Human, 21-22 and Y,
pubmed-meshheading:3860954-Chromosomes, Human, 6-12 and X,
pubmed-meshheading:3860954-Humans,
pubmed-meshheading:3860954-Leukemia, Myeloid, Acute,
pubmed-meshheading:3860954-Nucleic Acid Hybridization,
pubmed-meshheading:3860954-Oncogenes,
pubmed-meshheading:3860954-Translocation, Genetic
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
The role of the c-mos gene in the 8;21 translocation in human acute myeloblastic leukemia.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|