|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
16
|
|
pubmed:dateCreated |
1985-9-25
|
|
pubmed:abstractText |
Experiments reported here indicate a crude soybean extract, if defatted with acetone, effectively blocks cell transformation in vitro. An active component of this crude extract is the Bowman-Birk trypsin and chymotrypsin inhibitor. The chymotrypsin-inhibitory region of the Bowman-Birk inhibitor is responsible for suppressing in vitro transformation. Another low molecular weight soybean trypsin inhibitor does not significantly suppress transformation. The Bowman-Birk inhibitor (i) has an irreversible effect on the transformation process, (ii) can suppress radiation-induced transformation even when added to cultures many days after the carcinogen exposure, and (iii) is effective in its ability to suppress transformation when present in the medium at a concentration as low as 0.125 nM.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3860869-11272108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3860869-4357355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3860869-445479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3860869-4796800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3860869-6195356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3860869-6266659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3860869-6300832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3860869-6317687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3860869-6682011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3860869-6690989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3860869-6938973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3860869-6996568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3860869-7139867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3860869-7237415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3860869-723956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3860869-73387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3860869-791269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3860869-942051
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
82
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
5395-9
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:3860869-Acetone,
pubmed-meshheading:3860869-Animals,
pubmed-meshheading:3860869-Cell Transformation, Neoplastic,
pubmed-meshheading:3860869-Cells, Cultured,
pubmed-meshheading:3860869-Chymotrypsin,
pubmed-meshheading:3860869-Mice,
pubmed-meshheading:3860869-Mice, Inbred C3H,
pubmed-meshheading:3860869-Trypsin Inhibitor, Bowman-Birk Soybean,
pubmed-meshheading:3860869-Trypsin Inhibitors,
pubmed-meshheading:3860869-X-Rays
|
|
pubmed:year |
1985
|
|
pubmed:articleTitle |
Nanomolar concentrations of Bowman-Birk soybean protease inhibitor suppress x-ray-induced transformation in vitro.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
