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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1985-9-11
|
| pubmed:abstractText |
Routine cytogenetic studies were done in 174 consecutive patients with preleukemic or myelodysplastic syndromes (PL/MDS): 5 had the 5q - syndrome, 2 had refractory cytopenia, 43 had refractory anemia, 38 had refractory anemia with ringed sideroblasts, 69 had refractory anemia with excess blasts, 6 had refractory anemia with excess blasts in transition, and 11 had chronic myelomonocytic leukemia. Successful chromosome studies were accomplished in 167 patients (96%); 64 (37%) had a chromosomally abnormal clone. Abnormal clones were most common among patients who had refractory anemia with excess blasts (45%), refractory anemia with excess blasts in transition (60%), and chronic myelomonocytic leukemia (45%); they were least common among patients with refractory anemia (32%) and refractory anemia with ringed sideroblasts (21%). The two patients with refractory cytopenia had normal cytogenetic results. Each patient with the 5q - syndrome had a 5q-chromosome, as this is a prerequisite for the diagnosis. The two most common structural abnormalities were deletion of part of a chromosome 5 long arm (17 patients) and deletion of part of a chromosome 20 long arm (8 patients). Nonspecific structural abnormalities of chromosomes 1, 3, 6, and 17 were also common. The most common numeric abnormalities were monosomy 5 (7 patients), monosomy 7 (4 patients), loss of the Y chromosome (9 patients), and trisomy 8 (20 patients). No chromosome abnormalities were specifically associated with any PL/MDS classification.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0025-6196
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
60
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
507-16
|
| pubmed:dateRevised |
2007-10-29
|
| pubmed:meshHeading |
pubmed-meshheading:3860707-Adult,
pubmed-meshheading:3860707-Aged,
pubmed-meshheading:3860707-Anemia, Aplastic,
pubmed-meshheading:3860707-Bone Marrow Diseases,
pubmed-meshheading:3860707-Chromosome Aberrations,
pubmed-meshheading:3860707-Chromosome Deletion,
pubmed-meshheading:3860707-Chromosome Disorders,
pubmed-meshheading:3860707-Chromosomes, Human, 19-20,
pubmed-meshheading:3860707-Chromosomes, Human, 4-5,
pubmed-meshheading:3860707-Chromosomes, Human, 6-12 and X,
pubmed-meshheading:3860707-Female,
pubmed-meshheading:3860707-Humans,
pubmed-meshheading:3860707-Karyotyping,
pubmed-meshheading:3860707-Leukemia, Myeloid,
pubmed-meshheading:3860707-Male,
pubmed-meshheading:3860707-Middle Aged,
pubmed-meshheading:3860707-Monosomy,
pubmed-meshheading:3860707-Preleukemia,
pubmed-meshheading:3860707-Sex Chromosome Aberrations,
pubmed-meshheading:3860707-Trisomy,
pubmed-meshheading:3860707-Y Chromosome
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Cytogenetic studies in 174 consecutive patients with preleukemic or myelodysplastic syndromes.
|
| pubmed:publicationType |
Journal Article
|