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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1985-7-17
|
| pubmed:abstractText |
Single-dose studies in man have shown that omeprazole is a potent inhibitor of acid secretion stimulated by betazole, pentagastrin, modified sham-feeding and peptone. The degree of inhibition is dose-dependent and correlates to the area under the plasma omeprazole concentration-time curve. The duration of action of a single oral dose is 2-3 days and not dependent on a sustained plasma concentration of omeprazole. During repeated once-daily administration the level of acid inhibition increases over the first 5 days, after which it stabilises. With once-daily omeprazole treatment it is possible to almost abolish 24-hour intragastric acidity in the majority of DU patients.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0085-5928
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
108
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
105-12
|
| pubmed:dateRevised |
2008-2-13
|
| pubmed:meshHeading |
pubmed-meshheading:3858972-Anti-Ulcer Agents,
pubmed-meshheading:3858972-Benzimidazoles,
pubmed-meshheading:3858972-Dose-Response Relationship, Drug,
pubmed-meshheading:3858972-Gastric Acid,
pubmed-meshheading:3858972-Humans,
pubmed-meshheading:3858972-Male,
pubmed-meshheading:3858972-Omeprazole,
pubmed-meshheading:3858972-Pentagastrin
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Acid inhibitory characteristics of omeprazole in man.
|
| pubmed:publicationType |
Journal Article
|