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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1985-7-23
|
| pubmed:abstractText |
Plasma cortisol levels were monitored for 2 hours after an intramuscular injection of 75 mg desipramine in 13 endogenous depressives and 20 normal controls. Endogenous depressives had a significantly reduced cortisol response in comparison to normal controls, not explained by sex, age, or baseline cortisol differences between groups. A lack of a cortisol rise of 1.5 micrograms/dl above baseline by 45 minutes discriminated best, with 7 of 13 depressives (55%) being identified in contrast to only 1 of 20 normals (5%). The results suggest that this may be a useful biological test with acceptable sensitivity (55%) and excellent specificity (95%). Furthermore, these data suggest that norepinephrine may be stimulatory to cortisol in man.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0165-1781
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
14
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
225-33
|
| pubmed:dateRevised |
2008-4-17
|
| pubmed:meshHeading |
pubmed-meshheading:3858895-Adult,
pubmed-meshheading:3858895-Depressive Disorder,
pubmed-meshheading:3858895-Desipramine,
pubmed-meshheading:3858895-Female,
pubmed-meshheading:3858895-Humans,
pubmed-meshheading:3858895-Hydrocortisone,
pubmed-meshheading:3858895-Injections, Intramuscular,
pubmed-meshheading:3858895-Male,
pubmed-meshheading:3858895-Middle Aged
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
The cortisol response to desipramine in endogenous depressives and normal controls: preliminary findings.
|
| pubmed:publicationType |
Journal Article
|