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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1985-7-22
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pubmed:abstractText |
A high rate of aerobic glycolysis was catalyzed by rat-1 cells transfected with a ras oncogene (ras cells); rat-1 cells and rat-1 cells transfected with myc oncogene (myc cells) showed a low rate of glycolysis that was increased after exposure of the cells to type B transforming growth factor (TGF-beta). The uptake of radioactive methylaminoisobutyric acid or L-methionine via system A of amino acid transport also was accelerated after exposure of these cells to TGF-beta, with the myc cells being most sensitive and the ras cells least sensitive. Methionine was found to be a potent inhibitor of glycolysis in ras cells as well as in rat-1 or myc cells that were exposed to TGF-beta. We propose a relationship between the product of the ras oncogene (p21) and the protein(s) induced by exposure to TGF-beta.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3858838-2983339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3858838-3871948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3858838-4185156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3858838-4268695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3858838-4335068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3858838-447744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3858838-6210152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3858838-6219995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3858838-6308472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3858838-6438624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3858838-6707100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3858838-6712686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3858838-6757258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3858838-721825
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3535-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3858838-Aminoisobutyric Acids,
pubmed-meshheading:3858838-Animals,
pubmed-meshheading:3858838-Biological Transport, Active,
pubmed-meshheading:3858838-Cell Transformation, Neoplastic,
pubmed-meshheading:3858838-Cycloheximide,
pubmed-meshheading:3858838-Dose-Response Relationship, Drug,
pubmed-meshheading:3858838-Fibroblasts,
pubmed-meshheading:3858838-Glycolysis,
pubmed-meshheading:3858838-Methionine,
pubmed-meshheading:3858838-Oncogenes,
pubmed-meshheading:3858838-Peptides,
pubmed-meshheading:3858838-Platelet-Derived Growth Factor,
pubmed-meshheading:3858838-Rats,
pubmed-meshheading:3858838-Transfection,
pubmed-meshheading:3858838-Transforming Growth Factors
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pubmed:year |
1985
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pubmed:articleTitle |
Glycolysis and methylaminoisobutyrate uptake in rat-1 cells transfected with ras or myc oncogenes.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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