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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1985-4-16
|
| pubmed:abstractText |
To study the effects of hyperbilirubinemia on platelet thromboxane A2 (TxA2) and vascular prostacyclin (PGI2) production in newborn infants, the stable metabolites of these prostanoids, thromboxane B2 (TxB2) and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), respectively, were studied in 48 hyperbilirubinemic (serum total bilirubin concentrations between 100 and 320 mumol/1) term infants before and after phototherapy at the age of 2-10 days. The effect of bilirubin on platelet TxA2 production was also determined in vitro. The production of TxB2 during spontaneous clotting in infants with moderate hyperbilirubinemia (serum total bilirubin 171-250 mumol/1) was higher than that in infants with mild (serum bilirubin 100-170 mumol/1) or marked (serum bilirubin greater than 250 mumol/1) jaundice. There was, in addition, an inverse correlation (r = -0.625, p less than 0.01, n = 20) between TxB2 formation and serum total bilirubin concentrations in infants with total bilirubin concentrations over 170 mumol/1. Platelet TxB2 production was enhanced at low (200 mumol/1), but decreased at high (400-1600 mumol/1) concentrations of bilirubin in vitro. Although phototherapy reduced the serum bilirubin levels, it did not change the TxB2 generation. Neither hyperbilirubinemia nor phototherapy had any effect on the plasma 6-keto-PGF1 alpha levels. The results indicate a dual effect of bilirubin on the TxA2 production in neonatal platelets. This may contribute to the hemostatic disturbances in neonatal hyperbilirubinemia.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0262-1746
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
17
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
97-105
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:3856285-6-Ketoprostaglandin F1 alpha,
pubmed-meshheading:3856285-Blood Platelets,
pubmed-meshheading:3856285-Humans,
pubmed-meshheading:3856285-Infant, Newborn,
pubmed-meshheading:3856285-Jaundice, Neonatal,
pubmed-meshheading:3856285-Phototherapy,
pubmed-meshheading:3856285-Thromboxane A2,
pubmed-meshheading:3856285-Thromboxane B2,
pubmed-meshheading:3856285-Thromboxanes
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Immunoreactive thromboxane B2 and 6-keto-prostaglandin F1 alpha in neonatal hyperbilirubinemia.
|
| pubmed:publicationType |
Journal Article
|