Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1985-3-27
pubmed:databankReference
pubmed:abstractText
A transforming N-ras gene has been cloned from acute myeloblastic leukemia bone marrow cells, in parallel with the N-ras gene derived from fibroblasts of the same patient. N-ras derived from fibroblasts lacked focus-forming activity in NIH/3T3 cells, indicating that gene activation in the leukemia cells must have occurred by a somatic event. Construction of chimeric molecules between the transforming and the normal N-ras genes and subsequent biological and sequence analysis of these constructs revealed that the transforming gene was altered by a point mutation changing amino acid 12 of the N-ras protein from glycine to aspartic acid.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-271968, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-286319, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-322279, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-333431, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6086315, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6247068, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6253810, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6254843, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6265801, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6283357, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6283384, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6285355, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6286138, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6287003, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6287287, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6290897, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6298635, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6298638, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6304521, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6304883, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6306471, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6308465, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6308467, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6308661, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6310408, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6320011, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6320174, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6418375, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6572002, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6572964, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6582353, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6582476, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6605534, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6616621, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6683594, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6695174, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6695178, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6700714, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6843652, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-6866079, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-7063039, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-7133135, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-7144906, http://linkedlifedata.com/resource/pubmed/commentcorrection/3856237-7177195
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
82
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
879-82
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Activation of an N-ras gene in acute myeloblastic leukemia through somatic mutation in the first exon.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't