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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1979-11-21
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pubmed:abstractText |
In pancreatic islets from normal Chinese hamsters preloaded with 45Ca2+, glucose-induced biphasic insulin release was associated with increased 45Ca2+ efflux; islets from diabetic hamsters showed decreased insulin release and no increase in 45Ca2+ efflux. The lack of stimulated 45Ca2+ efflux persisted even when glucose-induced insulin release was potentiated by 3-isobutyl-1-methylxanthine. Since glucose-stimulated 45Ca2+ uptake by diabetic islets was not impaired, a defect in intracellular Ca2+ handling may be involved in the defective insulin release of the diabetic Chinese hamster.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/384998-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/384998-187518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/384998-212335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/384998-332717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/384998-353076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/384998-357448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/384998-360949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/384998-369829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/384998-4217290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/384998-4217291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/384998-4552828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/384998-4615023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/384998-4830228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/384998-5320561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/384998-5436367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/384998-99051
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
180
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
233-6
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:384998-Animals,
pubmed-meshheading:384998-Calcium,
pubmed-meshheading:384998-Cricetinae,
pubmed-meshheading:384998-Cricetulus,
pubmed-meshheading:384998-Diabetes Mellitus,
pubmed-meshheading:384998-Female,
pubmed-meshheading:384998-Insulin,
pubmed-meshheading:384998-Islets of Langerhans,
pubmed-meshheading:384998-Male,
pubmed-meshheading:384998-Proteins,
pubmed-meshheading:384998-Rats
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pubmed:year |
1979
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pubmed:articleTitle |
Defective calcium handling and insulin release in islets from diabetic Chinese hamsters.
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pubmed:publicationType |
Journal Article,
In Vitro
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