Linked Life Data

3846592

Source:http://linkedlifedata.com/resource/pubmed/id/3846592

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1985-7-25
pubmed:abstractText
The influence of a single intravenous dose of antibiotic on faecal flora and the emergence of Clostridium difficile was studied in volunteers. Seventy-eight volunteers (13 groups of 6 receiving 5 penicillins and 8 cephalosporins) were given a single intravenous dose of antibiotic. Results were compared with a control group of 6 volunteers who did not receive an antibiotic. Changes in the faecal flora were monitored over two weeks. Only cephalosporins were associated with emergence of Cl. difficile, penicillins and controls were not. Frequency of emergence of Cl. difficile in the 6 volunteers in each of the cephalosporin groups were as follows: cephaloridine 0, cephazolin, 1 cefuroxime 1, cefoxitin 2, cefotaxime 2, latamoxef 3, ceftriaxone 2, cefotetan 4. Latamoxef (moxalactam) was associated with a significant rise in total aerobic bacterial counts largely due to increased counts of enterococci. Cefotetan eliminated Escherichia coli and Bacteroides fragilis from the faecal flora three days after administration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0305-7453
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
319-26
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
The influence of single dose intravenous antibiotics on faecal flora and emergence of Clostridium difficile.
pubmed:publicationType
Journal Article, Clinical Trial, Controlled Clinical Trial