Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1985-5-17
pubmed:abstractText
The pharmacokinetics and bacteriological efficacies of penicillin G, ceftriaxone, vancomycin, and imipenem were determined in rabbits with experimental meningitis caused by Streptococcus pneumoniae strains with different penicillin susceptibilities. Drug dosages were adjusted to attain peak concentrations in serum that were similar to those observed in infants and children. In animals infected with a penicillin-susceptible (MBC, 0.008 micrograms/ml) pneumococcus, penicillin G and ceftriaxone reduced the number of organisms in cerebrospinal fluid (CSF) by greater than or equal to 4.14 log10 CFU/ml after single doses and after 9-h continuous infusions. A single large dose (50 mg/kg) of penicillin G was comparatively ineffective (-2.15 log10 CFU/ml) against a relatively penicillin-resistant (MBC, 0.5 micrograms/ml) strain, whereas ceftriaxone therapy resulted in a 3.66- and 4.77-log10 CFU/ml reduction after single doses and 9-h continuous infusions, respectively. In animals in which meningitis was caused by a penicillin-resistant (MBC, 8.0 micrograms/ml) pneumococcus, a single dose of penicillin (50 or 150 mg/kg) or of ceftriaxone failed to lower the number of organisms in CSF. Vancomycin and imipenem reduced the counts in CSF by at least 2.19 and 4.10 log10 CFU/ml after single doses and 9-h infusions, respectively. In all experiments, a bactericidal titer of greater than or equal to 1:8 in CSF was necessary to achieve a maximal bacteriological effect.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3845793-17817, http://linkedlifedata.com/resource/pubmed/commentcorrection/3845793-19570, http://linkedlifedata.com/resource/pubmed/commentcorrection/3845793-33551, http://linkedlifedata.com/resource/pubmed/commentcorrection/3845793-4153968, http://linkedlifedata.com/resource/pubmed/commentcorrection/3845793-4157341, http://linkedlifedata.com/resource/pubmed/commentcorrection/3845793-5328466, http://linkedlifedata.com/resource/pubmed/commentcorrection/3845793-6116903, http://linkedlifedata.com/resource/pubmed/commentcorrection/3845793-6134039, http://linkedlifedata.com/resource/pubmed/commentcorrection/3845793-6217785, http://linkedlifedata.com/resource/pubmed/commentcorrection/3845793-6280599, http://linkedlifedata.com/resource/pubmed/commentcorrection/3845793-6306192, http://linkedlifedata.com/resource/pubmed/commentcorrection/3845793-6322679, http://linkedlifedata.com/resource/pubmed/commentcorrection/3845793-6322681, http://linkedlifedata.com/resource/pubmed/commentcorrection/3845793-6365874, http://linkedlifedata.com/resource/pubmed/commentcorrection/3845793-6372473, http://linkedlifedata.com/resource/pubmed/commentcorrection/3845793-6728704, http://linkedlifedata.com/resource/pubmed/commentcorrection/3845793-6904489, http://linkedlifedata.com/resource/pubmed/commentcorrection/3845793-6907271, http://linkedlifedata.com/resource/pubmed/commentcorrection/3845793-6912777, http://linkedlifedata.com/resource/pubmed/commentcorrection/3845793-7247389, http://linkedlifedata.com/resource/pubmed/commentcorrection/3845793-7282738, http://linkedlifedata.com/resource/pubmed/commentcorrection/3845793-72950, http://linkedlifedata.com/resource/pubmed/commentcorrection/3845793-8418, http://linkedlifedata.com/resource/pubmed/commentcorrection/3845793-8756
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
141-5
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Antimicrobial therapy of experimental meningitis caused by Streptococcus pneumoniae strains with different susceptibilities to penicillin.
pubmed:publicationType
Journal Article