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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1986-5-14
|
| pubmed:abstractText |
A teratological study was carried out in New Zealand White rabbits in order to examine the teratogenic potentiality of HPMCAS, a useful pharmaceutical excipient. HPMCAS was orally administered at dose levels of 625, 1,250 and 2,500 mg/kg/day for a period of 13 days from day 6 to day 18 of gestation. All pregnant females were sacrificed on day 29 of gestation and their fetuses were examined. The administration of HPMCAS during a period of organogenesis produced no embryotoxic and teratogenic effects as well as no influence on behavior, appearance and growth of animals.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0388-1350
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10 Suppl 2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
227-34
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:3841675-Abnormalities, Drug-Induced,
pubmed-meshheading:3841675-Administration, Oral,
pubmed-meshheading:3841675-Animals,
pubmed-meshheading:3841675-Body Weight,
pubmed-meshheading:3841675-Bone and Bones,
pubmed-meshheading:3841675-Drinking,
pubmed-meshheading:3841675-Eating,
pubmed-meshheading:3841675-Female,
pubmed-meshheading:3841675-Fetus,
pubmed-meshheading:3841675-Methylcellulose,
pubmed-meshheading:3841675-Pregnancy,
pubmed-meshheading:3841675-Rabbits
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Teratological study of hydroxypropylmethylcellulose acetate succinate in rabbits.
|
| pubmed:publicationType |
Journal Article
|