Linked Life Data

3841048

Source:http://linkedlifedata.com/resource/pubmed/id/3841048

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1986-2-13
pubmed:abstractText
Metabolic disposition and subchronic oral toxicologic studies were conducted on a new synthetic sweetener, Oxime V. Based on radioactivity assay, the compound was readily absorbed and metabolized. Excretion was nearly quantitative 48 hours after dosing the rat, dog, and rhesus monkey. The major metabolites were formed by oxidation and reduction of the cyclohexadiene ring, oxidation of the aldoxime and dimethyl ether moieties followed by conjugation with glycine, thiomethylation of the ring, and O-glucuronidation of the aldoxime. A two-month feeding study was conducted with male adult rats. The average consumption of Oxime V was 396.5 mg/kg per day by rats fed a diet containing 0.6% of the test compound. No treatment related histopathologic lesion was observed in the liver, kidney, spleen, and testes. The liver weight relative to the body weight and serum bilirubin level were increased.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0148-0545
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
195-206
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Metabolic and toxicologic study of an artificial sweetener, oxime V.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.