Linked Life Data

3839976

Source:http://linkedlifedata.com/resource/pubmed/id/3839976

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3 Pt 1
pubmed:dateCreated
1985-10-10
pubmed:abstractText
The hydrophobic nature [Am. J. Physiol. 244 (Gastrointest. Liver Physiol. 7): G561-G568, 1983] of the mucosal lining of canine oxyntic tissue has been characterized by rinsing with saline or a phospholipid solvent (hexane) and by measuring the maximum contact angles as droplets of a hydrophilic liquid (saline) and a hydrophobic liquid (olive oil) advance over that surface. The results are consistent with the luminal lining as an adsorbed monolayer of surfactant whose outer shell of packed fatty acid chains resemble polyethylene. Phospholipid (dipalmitoyl lecithin) monolayers deposited in vitro and polyethylene were both found to be readily wetted by stomach mucus, reducing advancing contact angles (theta) by 74 and 83%, respectively, while eliminating altogether the minimum contact angle for receding saline. Taking theta values for "dry" tissue as the most conservative, the reduction in surface energy imparted by mucus was estimated as 30.3 ergs X cm-2, which dispels the objection that, on thermodynamic grounds, surfactant must form a bilayer rather than a monolayer. Thus, as a powerful wetting agent, mucus would play an important role in stabilizing and replenishing the absorbed surfactant monolayer proposed as the physical basis for the gastric mucosal barrier.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
249
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
G342-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Gastric mucosal barrier: stabilization of hydrophobic lining to the stomach by mucus.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't