Linked Life Data

3839905

Source:http://linkedlifedata.com/resource/pubmed/id/3839905

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6032
pubmed:dateCreated
1985-10-18
pubmed:abstractText
Acetylcholine receptors (AChRs) are highly concentrated in the small fraction (approximately 0.1%) of the skeletal muscle fibre surface that comprises the postsynaptic membrane of the neuromuscular junction (Fig. 1a). In adult murine muscle, for example, AChRs are packed at a density of over 15,000 per micron2 in postsynaptic membrane, whereas their density is less than 30 per micron2 in extrasynaptic membrane. Because synaptic AChRs turn over they must be replaced, and it is interesting to consider where the new AChRs that maintain synaptic aggregates are synthesized. One possibility is that AChRs are synthesized uniformly along the length of the multinucleated muscle fibre; in this case, AChRs might be redistributed to or selectively stabilized at the synapse, as probably occurs during synapse formation. Alternatively, AChRs might be preferentially synthesized near synapses, a possibility that would suggest that innervation can influence not only where AChRs are inserted or accumulate but also where they are synthesized. In support of this second possibility, we report here that AChR messenger RNA is more abundant near to than far from synapses in adult muscle fibres.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:volume
317
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
66-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Concentration of acetylcholine receptor mRNA in synaptic regions of adult muscle fibres.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't