Linked Life Data

3839884

Source:http://linkedlifedata.com/resource/pubmed/id/3839884

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1985-10-9
pubmed:abstractText
Treatment of normal animals with the thymothyroid hormone, leucogenenol, increases the rate at which appropriate committed precursor cells of the bone marrow develop sequentially into their corresponding functional cells: neutrophils, lymphocytes and red blood cells. Hence following treatment with leucogenenol, at a time that is dependent on the quantity of leucogenenol injected, there is a temporary increase in the bone marrow of the relative concentrations of early forms of committed cells such as myeloblasts. However, following treatment of bilaterally adrenalectomized rats with leucogenenol the early forms of committed cells in the bone marrow, such as myeloblasts, instead of showing a temporary relative increase show a temporary significant decrease in concentration. A new compound, adroxazine, C34H65NO2, was isolated from the methanol extract of bovine adrenal tissue. This compound, on injection into bilaterally adrenalectomized rats, causes leucogenenol to have the same effect on the development of their bone marrow cells as it does in normal rats. Adroxazine is present in the cortex of the adrenals and in blood serum. It is suggested that the population of primitive replicating cells is controlled by the concentration of adroxazine in the serum.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0024-3205
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
963-9
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Adroxazine, a hormone of the adrenals that stimulates the rate of replication of bone marrow stem cells.
pubmed:publicationType
Journal Article