Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1985-8-2
pubmed:abstractText
A number of unique sequence recombinant DNA clones were isolated from a recombinant DNA library constructed from DNA enriched for chromosome 21 by flow sorting. Of these, five were mapped to chromosome 21 using a somatic cell hybrid. Regional mapping of these probes and of a probe previously assigned to chromosome 21, was carried out with the aid of chromosome 21 rearrangements using both chromosome sorting and a somatic cell hybrid. Three probes were shown to be located on either side of the breakpoint 21q21.2. Two of the probes were shown to identify restriction fragment length polymorphisms (RFLPs) with high rare-allele frequencies (0.46 and 0.43). A Bgl II RFLP revealed the parental origin of non-disjunction in three of ten families with Down's syndrome.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3839305-1195397, http://linkedlifedata.com/resource/pubmed/commentcorrection/3839305-265567, http://linkedlifedata.com/resource/pubmed/commentcorrection/3839305-291033, http://linkedlifedata.com/resource/pubmed/commentcorrection/3839305-293684, http://linkedlifedata.com/resource/pubmed/commentcorrection/3839305-322279, http://linkedlifedata.com/resource/pubmed/commentcorrection/3839305-331256, http://linkedlifedata.com/resource/pubmed/commentcorrection/3839305-6162882, http://linkedlifedata.com/resource/pubmed/commentcorrection/3839305-6211674, http://linkedlifedata.com/resource/pubmed/commentcorrection/3839305-6230306, http://linkedlifedata.com/resource/pubmed/commentcorrection/3839305-6247908, http://linkedlifedata.com/resource/pubmed/commentcorrection/3839305-6281170, http://linkedlifedata.com/resource/pubmed/commentcorrection/3839305-6293786, http://linkedlifedata.com/resource/pubmed/commentcorrection/3839305-6324578, http://linkedlifedata.com/resource/pubmed/commentcorrection/3839305-6456416, http://linkedlifedata.com/resource/pubmed/commentcorrection/3839305-6461845, http://linkedlifedata.com/resource/pubmed/commentcorrection/3839305-6953442, http://linkedlifedata.com/resource/pubmed/commentcorrection/3839305-7140365, http://linkedlifedata.com/resource/pubmed/commentcorrection/3839305-845942, http://linkedlifedata.com/resource/pubmed/commentcorrection/3839305-881736
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0305-1048
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4125-32
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Cloned DNA probes regionally mapped to human chromosome 21 and their use in determining the origin of nondisjunction.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't