Linked Life Data

3838661

Source:http://linkedlifedata.com/resource/pubmed/id/3838661

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1985-5-17
pubmed:abstractText
Friedreich's ataxia (FA) is a progressive, spinocerebellar, degenerative, neuromuscular disease that is frequently associated with hypertrophic cardiomyopathy as part of the clinical illness. Hypertrophic cardiomyopathy associated with FA can be seen with or without obstruction to the left ventricle outflow tract. We present the postmortem findings in a case of FA with dilated (congestive) cardiomyopathy. At autopsy, the heart was enlarged with all four chambers dilated; no ventricular hypertrophy or aortic outflow obstruction was present. Microscopic sections of myocardium revealed myocyte hypertrophy, atrophy, and focal interstitial fibrosis. Findings of dilated cardiomyopathy at necropsy supported the antemortem clinical impression. Although FA has been reported to be associated rarely with dilated cardiomyopathy, postmortem documentation of dilated cardiomyopathy with FA has not been shown previously, to our knowledge. The mechanism of either form of myocardial disease in patients with FA is presently speculative.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0003-9985
pubmed:author
pubmed:issnType
Print
pubmed:volume
109
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
454-6
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Dilated cardiomyopathy associated with Friedreich's ataxia.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Case Reports