Linked Life Data

3836267

Source:http://linkedlifedata.com/resource/pubmed/id/3836267

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1986-8-18
pubmed:abstractText
The development of thermotolerance in L1A2 cells in vitro was investigated after fractionated hyperthermia at 42 degrees C. A single pretreatment of 90 min at 42 degrees C resulted in maximal thermotolerance at a 10 h fractionation interval with a thermotolerance ratio (TTR) of approximately 4.5. Thermotolerance was maintained at this level if the cells were exposed to 1-3 additional 90 min pretreatments separated by 10 h intervals. At a 6 h fractionation interval, where thermotolerance was still developing, additional 90 min pretreatments raised the level of thermotolerance to the level induced by the 10 h interval; the TTR increased from 2.1 to 4.5. Intervals of 20 and 24 h, at which there was decay but not complete disappearance of thermotolerance, did not induce such a build-up, and the TTR remained constant at 2.5 and 1.6, respectively. With 2 h fractionation intervals, where a single pretreatment did not induce thermotolerance, no thermotolerance was induced by additional pretreatments. With a shorter preheating time (e.g. 45 min at 42 degrees C) administration of a single pretreatment induced maximal thermotolerance after 6 h with a TTR of 3.0; additional 45 min pretreatments separated by 6 h intervals maintained this level. The thermotolerance induced by multifractioned hyperthermia as described above decayed in a similar way to that of cells exposed to a single pretreatment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0265-6736
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
193-203
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Studies on fractionated hyperthermia in L1A2 tumour cells in vitro: response to multiple equal heat fractions.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't