Linked Life Data

3833056

Source:http://linkedlifedata.com/resource/pubmed/id/3833056

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1986-4-29
pubmed:abstractText
Resistance to phagocytosis of Yersinia pseudotuberculosis by mouse resident macrophages was investigated using a highly virulent plasmid-bearing strain and its low-virulent plasmid-free derivative. It was found that plasmid-bearing and plasmid-less bacteria did not resist the ingestion step nor inhibit the oxidative burst and phagolysosomal fusion in the peritoneal macrophages. These in vitro data were further confirmed by the study of bacterial survival in infected mice. Bacteria from plasmid-bearing and plasmid-free strains were similarly eliminated during the first hours of infection in the liver and in the peritoneal cavity. Our results therefore suggest that plasmid-mediated virulence is not related to the resistance to the bactericidal activity of fixed macrophages of the reticuloendothelial system during the early phase of infection, and that plasmid-encoded factors are expressed after a latency period by an unknown mechanism.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0769-2609
pubmed:author
pubmed:issnType
Print
pubmed:volume
136B
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
283-94
pubmed:dateRevised
2007-7-23
pubmed:meshHeading
pubmed:articleTitle
Role of virulence-associated plasmid in the uptake and killing of Yersinia pseudotuberculosis by resident macrophages.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't