Linked Life Data

3828541

Source:http://linkedlifedata.com/resource/pubmed/id/3828541

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1987-5-13
pubmed:abstractText
Standardization of bronchial challenge (BC) in order to improve repeatability of both non-specific and specific challenges is desirable. In the tidal volume breathing BC (tBC), the patient inhales bronchoconstrictor during the entire inspiratory phase of the tidal volume breathing. We determined 2 min ventilation (VE) at each histamine concentration during 187 BCs. Thirty-four patients were challenged twice. We used a standard technique (Cockcroft), except for our patient operated Pari nebulizer. Between-subject (SD = 37%) as well as within-subject (SD = 21%) (p less than 0.01) variations in VE were observed. Furthermore, VE during inhalation of threshold dose (VE-threshold) was smaller than VE during inhalation of the previous dose (VE-threshold-1) (p less than 0.001). For paired differences in VE during two challenges, the within subject SD was 21%. The between subject SD for VE was 32%. VE-threshold was lower in first challenge (p less than 0.001). VE threshold in both challenges was significantly lower than VE-threshold-1. These observations indicate that the respiratory pattern during tBC needs further standardization and that respiratory frequency and inspiratory time during tBC would be worth investigating.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0395-3890
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
517-22
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Bronchial challenge: ventilation during 'tidal volume breathing' inhalation is not constant.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't