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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1987-4-1
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pubmed:abstractText |
A mitochondrial cytochrome P-450 fraction, which catalyzed 25-hydroxylation of vitamin D3 much more efficiently than intact mitochondria was isolated from livers of male and female rats. For comparison, a microsomal cytochrome P-450 fraction was isolated by the same procedures. The mitochondrial cytochrome P-450 from female rats catalyzed 25-hydroxylation as efficiently as the same material from male rats. The microsomal 25-hydroxylation was male specific. The 25-hydroxylase activity in intact mitochondria and the 25-hydroxyvitamin D3 concentration in serum were similar in male and female rats. There was no correlation between the 25-hydroxylase activity in microsomal cytochrome P-450 and the 25-hydroxyvitamin D3 concentration in serum.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0006-291X
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
13
|
pubmed:volume |
142
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
999-1005
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3827911-Animals,
pubmed-meshheading:3827911-Calcifediol,
pubmed-meshheading:3827911-Cytochrome P-450 Enzyme System,
pubmed-meshheading:3827911-Female,
pubmed-meshheading:3827911-Hydroxylation,
pubmed-meshheading:3827911-Male,
pubmed-meshheading:3827911-Microsomes, Liver,
pubmed-meshheading:3827911-Mitochondria, Liver,
pubmed-meshheading:3827911-Rats,
pubmed-meshheading:3827911-Rats, Inbred Strains,
pubmed-meshheading:3827911-Sex Characteristics
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pubmed:year |
1987
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pubmed:articleTitle |
25-hydroxylation of vitamin D3 in rat liver: roles of mitochondrial and microsomal cytochrome P-450.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|