3827829

Source:http://linkedlifedata.com/resource/pubmed/id/3827829

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0013227, umls-concept:C0597572, umls-concept:C1879547
pubmed:issue	3
pubmed:dateCreated	1987-4-1
pubmed:abstractText	Compounds possessing the characteristics of CoA thioesters of the hypolipidaemic peroxisome proliferators clofibric acid, nafenopin and ciprofibrate were formed on incubation of the drugs with rat liver microsomal fractions, ATP and CoA. The reactivity of the drugs correlated with their pharmacological potency. It is proposed that the active species of these compounds are their acyl-CoA thioesters.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/3827829-1137719, http://linkedlifedata.com/resource/pubmed/commentcorrection/3827829-13249955, http://linkedlifedata.com/resource/pubmed/commentcorrection/3827829-13650640, http://linkedlifedata.com/resource/pubmed/commentcorrection/3827829-3995059, http://linkedlifedata.com/resource/pubmed/commentcorrection/3827829-4307302, http://linkedlifedata.com/resource/pubmed/commentcorrection/3827829-454514, http://linkedlifedata.com/resource/pubmed/commentcorrection/3827829-465511, http://linkedlifedata.com/resource/pubmed/commentcorrection/3827829-495982, http://linkedlifedata.com/resource/pubmed/commentcorrection/3827829-5493088, http://linkedlifedata.com/resource/pubmed/commentcorrection/3827829-6124394, http://linkedlifedata.com/resource/pubmed/commentcorrection/3827829-621438, http://linkedlifedata.com/resource/pubmed/commentcorrection/3827829-6240978, http://linkedlifedata.com/resource/pubmed/commentcorrection/3827829-6272750, http://linkedlifedata.com/resource/pubmed/commentcorrection/3827829-6656644, http://linkedlifedata.com/resource/pubmed/commentcorrection/3827829-6693413, http://linkedlifedata.com/resource/pubmed/commentcorrection/3827829-6766207, http://linkedlifedata.com/resource/pubmed/commentcorrection/3827829-6838659, http://linkedlifedata.com/resource/pubmed/commentcorrection/3827829-7130181, http://linkedlifedata.com/resource/pubmed/commentcorrection/3827829-7147992, http://linkedlifedata.com/resource/pubmed/commentcorrection/3827829-7430088
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/2984726R
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Acyl Coenzyme A, http://linkedlifedata.com/resource/pubmed/chemical/Clofibrate, http://linkedlifedata.com/resource/pubmed/chemical/Clofibric Acid, http://linkedlifedata.com/resource/pubmed/chemical/Coenzyme A Ligases, http://linkedlifedata.com/resource/pubmed/chemical/FAA2 protein, S cerevisiae, http://linkedlifedata.com/resource/pubmed/chemical/Fibric Acids, http://linkedlifedata.com/resource/pubmed/chemical/Nafenopin, http://linkedlifedata.com/resource/pubmed/chemical/Propionates, http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins, http://linkedlifedata.com/resource/pubmed/chemical/ciprofibrate, http://linkedlifedata.com/resource/pubmed/chemical/clofibric acid-coenzyme A, http://linkedlifedata.com/resource/pubmed/chemical/long-chain-fatty-acid-CoA ligase
pubmed:status	MEDLINE
pubmed:month	Nov
pubmed:issn	0264-6021
pubmed:author	pubmed-author:AmigoLL, pubmed-author:BronfmanMM, pubmed-author:MoralesM NMN
pubmed:issnType	Print
pubmed:day	1
pubmed:volume	239
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	781-4
pubmed:dateRevised	2010-11-18
pubmed:meshHeading	pubmed-meshheading:3827829-Acyl Coenzyme A, pubmed-meshheading:3827829-Animals, pubmed-meshheading:3827829-Chromatography, High Pressure Liquid, pubmed-meshheading:3827829-Clofibrate, pubmed-meshheading:3827829-Clofibric Acid, pubmed-meshheading:3827829-Coenzyme A Ligases, pubmed-meshheading:3827829-Fibric Acids, pubmed-meshheading:3827829-Hydrolysis, pubmed-meshheading:3827829-Male, pubmed-meshheading:3827829-Microsomes, Liver, pubmed-meshheading:3827829-Nafenopin, pubmed-meshheading:3827829-Propionates, pubmed-meshheading:3827829-Rats, pubmed-meshheading:3827829-Rats, Inbred Strains, pubmed-meshheading:3827829-Repressor Proteins, pubmed-meshheading:3827829-Saccharomyces cerevisiae Proteins, pubmed-meshheading:3827829-Spectrophotometry, Ultraviolet
pubmed:year	1986
pubmed:articleTitle	Activation of hypolipidaemic drugs to acyl-coenzyme A thioesters.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't