Linked Life Data

3826286

Source:http://linkedlifedata.com/resource/pubmed/id/3826286

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1987-4-23
pubmed:abstractText
To assess ultrastructural alterations to the corneal endothelium, eye drops containing vehicle alone or vehicle plus 0.004% thimerosal with or without 0.1% disodium ethylenediaminetetraacetate (Na2EDTA) were administered hourly over a 2-day period to rabbit corneas in vivo. Twenty of the corneas received a 5-mm keratectomy that removed epithelium and superficial stroma and 10 corneas were left intact. The vehicle alone had no effect on the endothelium of normal corneas. Thimerosal drops with or without Na2EDTA caused some clarification of the cytoplasm and dilatation of the endoplasmic reticulum of endothelial cells. The mitochondria had dilated cristae and membrane condensations. After keratectomy and vehicle only drops, the central endothelium showed a marked increase in microvilli and mitochondrial changes. Addition of either thimerosal or thimerosal plus Na2EDTA resulted in a slight decrease in membrane activity but an increase in intracellular edema and dilatation and damage to organelles. The peripheral areas were less affected than the center. Although the endothelium was stressed, most changes were considered reversible.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0093-7002
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
123-30
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
In vivo effects of thimerosal on the rabbit corneal endothelium: an ultrastructural study.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't