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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
1987-4-21
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pubmed:abstractText |
3H-N-methylspiperone (3H-NMSP) was used to label dopamine-2 and serotonin-2 in vivo in the mouse. The striatum/cerebellum binding ratio reached a maximum of 80 eight hours after intravenous administration of 3H-NMSP. The frontal cortex/cerebellum ratio was 5 one hour after injection. The binding of 3H-NMSP was saturable in the frontal cortex and cerebellum between doses of 10 and 1,000 micrograms/kg. Between 0.01 and 10 micrograms/kg the ratio total/nonspecific binding increased from 14 to 21. Inhibition of 3H-NMSP binding in the frontal cortex and striatum by ketanserin, a selective serotonin-2 antagonist, demonstrated that 20% of the total binding in the striatum was to serotonin-2 receptors and 91% of the total binding in the frontal cortex was to serotonin-2 receptors. Compared to 3H-spiperone, 3H-NMSP results in a much higher specific/nonspecific binding ratio in the striatum and frontal cortex and displays more than a two-fold higher brain uptake.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-N-methylspiperone,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Spiperone,
http://linkedlifedata.com/resource/pubmed/chemical/Tritium
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0024-3205
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
987-95
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3821368-Animals,
pubmed-meshheading:3821368-Cerebellum,
pubmed-meshheading:3821368-Corpus Striatum,
pubmed-meshheading:3821368-Dose-Response Relationship, Drug,
pubmed-meshheading:3821368-Frontal Lobe,
pubmed-meshheading:3821368-Male,
pubmed-meshheading:3821368-Metabolic Clearance Rate,
pubmed-meshheading:3821368-Mice,
pubmed-meshheading:3821368-Receptors, Dopamine,
pubmed-meshheading:3821368-Receptors, Serotonin,
pubmed-meshheading:3821368-Solubility,
pubmed-meshheading:3821368-Spiperone,
pubmed-meshheading:3821368-Tritium
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pubmed:year |
1987
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pubmed:articleTitle |
In vivo binding of 3H-N-methylspiperone to dopamine and serotonin receptors.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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