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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1987-3-31
|
| pubmed:abstractText |
The effect of verapamil on pressor response to Angiotensin II (A II) was investigated in rats. The responses to A II (10, 20, 40 ng, iv) was reduced after verapamil (50 and 100 micrograms, iv per rat) in a dose dependent manner. Treatment for 5 day with verapamil (18 mg/100 g/day, po) let to some reduction in basal blood pressure but pressor response to A II was not changed. Treatment for 20 days significantly reduced the basal blood pressure and increased the responsiveness to A II. it is concluded that Ca++ plays a major role in the pressor responses to A II and that chronic treatment with verapamil may reduce basal blood pressure.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0019-5499
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
30
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
145-8
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:3818041-Angiotensin II,
pubmed-meshheading:3818041-Animals,
pubmed-meshheading:3818041-Blood Pressure,
pubmed-meshheading:3818041-Drug Interactions,
pubmed-meshheading:3818041-Male,
pubmed-meshheading:3818041-Rats,
pubmed-meshheading:3818041-Rats, Inbred Strains,
pubmed-meshheading:3818041-Time Factors,
pubmed-meshheading:3818041-Verapamil
|
| pubmed:articleTitle |
The effect of acute and chronic treatment of verapamil on pressor response to angiotensin II in rats.
|
| pubmed:publicationType |
Journal Article
|