Linked Life Data

3815065

Source:http://linkedlifedata.com/resource/pubmed/id/3815065

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1987-3-30
pubmed:abstractText
Binding of [125I-5Val]angiotensin II and [125I-1Sar, 8Ile]angiotensin II to target sites in the hypothalamus of the Pekin duck was determined by quantitative receptor autoradiography and conventional membrane binding techniques. Circumventricular areas involved in body fluid homeostasis like the subfornical organ (SFO), median eminence and the anterior-ventral region of the third ventricle showed highest labeling density. Binding sites for angiotensin II were also found in the paraventricular and supraoptic nuclei. The physiological relevance of the labeled SFO angiotensin II receptor is indicated by similarities between rank orders of potency of angiotensin II analogues in displacing radiolabeled ligands and their physiological osmoregulatory potencies. Receptor density in the SFO of saltwater-acclimated ducks was increased 3-fold compared to non-acclimated freshwater ducks, indicating an up-regulation of the angiotensinergic system in ducks under conditions of dehydration or high salt intake.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
400
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
165-70
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Autoradiographic localization and characterization of circumventricular angiotensin II receptors in duck brain.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't