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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1987-4-17
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pubmed:abstractText |
Slices of guinea-pig cerebral cortex were incubated with [3H]-inositol at 37 degrees C before exposure to histamine or carbachol at 37 degrees C or 25 degrees C. Histamine-stimulated accumulation of [3H]-inositol 1-phosphate ([3H]-IP1) at 25 degrees C was only 5-7% of that at 37 degrees C, whereas for carbachol the response at 25 degrees C was 45-49% of that at 37 degrees C. The affinity of benzilylcholine, obtained from inhibition of carbachol-induced accumulation of [3H]-IP1 was similar at 25 degrees C and 37 degrees C, but the EC50 for carbachol was lower at 25 degrees C (20 +/- 2 microM) than at 37 degrees C (42 +/- 2 microM). The IC50 for histamine inhibition of [3H]-mepyramine binding to homogenates of guinea-pig cerebral cortex did not differ significantly at 25 degrees C and 37 degrees C. Histamine-induced accumulations of [3H]-IP2 and [3H]-IP3 at 25 degrees C, expressed as a percentage of the accumulation at 37 degrees C, were also much less than the corresponding value for carbachol. These observations imply that the locus or pathway(s) of agonist-induced formation of [3H]-IP1 are not the same for histamine and carbachol.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3814918-2981829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3814918-2992666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3814918-2998481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3814918-3007178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3814918-3007671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3814918-3010126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3814918-3978317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3814918-4042011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3814918-5343350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3814918-6095092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3814918-6099277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3814918-6121338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3814918-6130806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3814918-6135145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3814918-6146314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3814918-6321943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3814918-6327916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3814918-7150264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3814918-718161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3814918-729792
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
175-82
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3814918-Animals,
pubmed-meshheading:3814918-Carbachol,
pubmed-meshheading:3814918-Cerebral Cortex,
pubmed-meshheading:3814918-Guinea Pigs,
pubmed-meshheading:3814918-Histamine,
pubmed-meshheading:3814918-Inositol Phosphates,
pubmed-meshheading:3814918-Male,
pubmed-meshheading:3814918-N-Methylscopolamine,
pubmed-meshheading:3814918-Pyrilamine,
pubmed-meshheading:3814918-Scopolamine Derivatives,
pubmed-meshheading:3814918-Sugar Phosphates,
pubmed-meshheading:3814918-Temperature
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pubmed:year |
1987
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pubmed:articleTitle |
Differential effect of temperature on histamine- and carbachol-stimulated inositol phospholipid breakdown in slices of guinea-pig cerebral cortex.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, Non-U.S. Gov't
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