Linked Life Data

381206

Source:http://linkedlifedata.com/resource/pubmed/id/381206

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1979-10-24
pubmed:abstractText
The effect of chlorpromazine (CPZ) on diarrhea caused by enterotoxigenic Escherichia coli was tested in piglets since CPZ has been shown to be a potent antagonist to enterotoxins in vitro in a cell system and in vivo in a mouse model. Experimental diarrhea was induced in three litters of newborn piglets which were infected by mouth with 2 x 10(9)E. coli bacteria, which produce heat-labile (LT) and heat-stable (ST) enterotoxins. Treatment with CPZ given intramuscularly 1 h after the onset of diarrhea reversed fluid secretion in small intestine as well as dehydration, as judged by clinical criteria. A dose of 5 mg of CPZ per kg of body weight completely normalized the intestinal-fluid content measured 4 h after diarrhea developed, whereas 1 to 2 mg of CPZ per kg of body weight was somewhat less effective but still caused significant reduction of fluid (P < 0.001). Studies with radioactive [(35)S]CPZ showed preferential and dose-dependent uptake of (35)S in the intestinal mucosa, the radioactivity being evenly distributed in the membranes of both crypt and villus cells. The enzyme adenylate cyclase, which probably mediates the cellular effects of LT, was shown to have two- to threefold higher activity in the infected than in the uninfected animals. This activation was reduced about 50% by the CPZ treatment (2 mg/kg of body weight). In a preliminary field trial the effect of CPZ was tested in a spontaneous outbreak of diarrhea in piglets due to enterotoxinogenic E. coli. The animals were treated either with oral electrolyte solution and standard antimicrobial agents only (controls) or with 1 mg of CPZ per kg of body weight intramuscularly in addition to this treatment. The mean duration of diarrhea in CPZ-treated animals was significantly shorter, 4.1 h (n = 23), than that in controls, 7.2 h (P < 0.05).
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/381206-1101807, http://linkedlifedata.com/resource/pubmed/commentcorrection/381206-14907713, http://linkedlifedata.com/resource/pubmed/commentcorrection/381206-186235, http://linkedlifedata.com/resource/pubmed/commentcorrection/381206-197323, http://linkedlifedata.com/resource/pubmed/commentcorrection/381206-203862, http://linkedlifedata.com/resource/pubmed/commentcorrection/381206-213346, http://linkedlifedata.com/resource/pubmed/commentcorrection/381206-26915, http://linkedlifedata.com/resource/pubmed/commentcorrection/381206-357288, http://linkedlifedata.com/resource/pubmed/commentcorrection/381206-4154262, http://linkedlifedata.com/resource/pubmed/commentcorrection/381206-4268017, http://linkedlifedata.com/resource/pubmed/commentcorrection/381206-4300679, http://linkedlifedata.com/resource/pubmed/commentcorrection/381206-4553083, http://linkedlifedata.com/resource/pubmed/commentcorrection/381206-4565956, http://linkedlifedata.com/resource/pubmed/commentcorrection/381206-4827395, http://linkedlifedata.com/resource/pubmed/commentcorrection/381206-5883637
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
900-5
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Chlorpromazine reverses diarrhea in piglets caused by enterotoxigenic Escherichia coli.
pubmed:publicationType
Journal Article