Linked Life Data

3810012

Source:http://linkedlifedata.com/resource/pubmed/id/3810012

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1987-3-10
pubmed:abstractText
The oxidative metabolism of circulating neutrophils was studied in patients with Crohn's disease and ulcerative colitis. The production of superoxide anion (02-.) in patients with ulcerative colitis was markedly decreased irrespective of whether soluble or particulate, non-chemotactic or chemotactic stimuli were used. Crohn's disease neutrophils showed a just marginally diminished 02-. production. Disease activity, as defined by the Crohn's disease activity index, was negatively correlated with the neutrophil O2-. production in both diseases. In both Crohn's disease and in ulcerative colitis neutrophil hydrogen peroxide (H2O2) production was normal. It is concluded that the neutrophil function, as-assessed by superoxide anion production, is impaired in patients with inflammatory bowel disease. It is therefore suggested that the suboptimal microbicidal function of these cells, as demonstrated in the present study, may contribute to the disease process.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0036-5521
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1124-30
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Impaired activation of the neutrophil oxidative metabolism in chronic inflammatory bowel disease.
pubmed:publicationType
Journal Article