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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1987-2-24
|
| pubmed:abstractText |
A series of 26 mitomycin A analogues including 23 new ones was prepared by a variety of methods. The most useful methods were alkoxide exchange on mitomycin A and treatment of 7-hydroxymitosane with 3-substituted 1-phenyltriazenes. Many of the new analogues were superior to mitomycin C in the P388 leukemia assay and the more stringent subcutaneous B16 melanoma assay both in mice. Four of them gave long-term survivors in the latter assay. Quantitative correlations between log P and antitumor activity were not possible, but some guidelines for future analogue development are proposed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
30
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
168-73
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3806593-Animals,
pubmed-meshheading:3806593-Drug Evaluation, Preclinical,
pubmed-meshheading:3806593-Indicators and Reagents,
pubmed-meshheading:3806593-Leukemia P388,
pubmed-meshheading:3806593-Magnetic Resonance Spectroscopy,
pubmed-meshheading:3806593-Melanoma, Experimental,
pubmed-meshheading:3806593-Mice,
pubmed-meshheading:3806593-Mitomycins,
pubmed-meshheading:3806593-Structure-Activity Relationship
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
Preparation and antitumor activity of new mitomycin A analogues.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|