Linked Life Data

3803631

Source:http://linkedlifedata.com/resource/pubmed/id/3803631

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1987-3-5
pubmed:abstractText
Recently, the serotonergic nervous system has been receiving attention, as it participates in the hemodynamic regulation as well as in the pathogenesis of hypertension. The purpose of this experiment is to investigate the role of the central and peripheral serotonergic receptor in the hemodynamic responses induced by intracerebroventricular (i.c.v) administration of 5-hydroxytryptamine (5-HT). Eight week-old male spontaneously hypertensive rats (SHR) and age matched Wistar Kyoto rats (WKY) were used, and the experiment was performed under conscious and minimum restrained states. Five micrograms of 5-HT was given i.c.v. followed by i.c.v. administration of 200 micrograms ketanserin. Mean arterial pressure (MAP) and heart rate (HR) were observed continuously for 30 minutes. Then 5 micrograms of 5-HT was given i.c.v. again in the same rat (SHR -IC group, n = 7; WKY-IC group, n = 7). The rest of the rats received 200 micrograms of ketanserin intravenously (i.v.) after i.c.v. administration of 5 micrograms 5-HT, and the same amount of 5-HT was given i.c.v. after the ketanserin i.v. (SHR-IV group, n = 7; WKY-IV group, n = 6). Five-HT elicited a significant pressor response in all groups of rats and a slight non-significant increase in HR. In SHR-IC group and WKY-IC group, neither ketanserin i.c.v. nor the second 5-HT i.c.v. administration caused significant changes in MAP and HR. In SHR -IV group, i.v. ketanserin caused a significant decrease in MAP (-8.8 +/- 1.4 mmHg), but no significant change in MAP in WKY-IV group (-1.1 +/- 1.2 mmHg).(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0029-0661
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1222-9
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
[The effects of ketanserin on the hemodynamic response after intracerebroventricular administration of 5-hydroxytryptamine].
pubmed:publicationType
Journal Article, English Abstract