Switch to
Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1987-2-26
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pubmed:abstractText |
alpha-Neoendorphin-like immunoreactivities (alpha-NE-IR) were demonstrated in tissues from three patients with medullary carcinoma of the thyroid (MCT). A large amount of alpha-NE-IR was detected in the extracts of primary tumors and metastatic lymphatic tissues by a highly sensitive and specific radioimmunoassay (RIA). Gel filtration analyses showed two different molecular-weight forms of the alpha-NE-IR: One eluted at the void fraction and the other at the position of [125I]-alpha-NE on Sephadex (Pharmacia Fine Chemical, Uppsala, Sweden) G-50 chromatography. Immunohistochemical examination revealed the presence of alpha-NE-IR in the C-cell carcinoma. These data presumably reflect that alpha-NE, the opioid peptide derived from preproenkephalin B, is synthesized in the MCT.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
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pubmed:issn |
0008-543X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
277-80
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3802014-Adolescent,
pubmed-meshheading:3802014-Adult,
pubmed-meshheading:3802014-Carcinoma,
pubmed-meshheading:3802014-Chromatography, Gel,
pubmed-meshheading:3802014-Endorphins,
pubmed-meshheading:3802014-Female,
pubmed-meshheading:3802014-Humans,
pubmed-meshheading:3802014-Molecular Weight,
pubmed-meshheading:3802014-Protein Precursors,
pubmed-meshheading:3802014-Radioimmunoassay,
pubmed-meshheading:3802014-Thyroid Neoplasms
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pubmed:year |
1987
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pubmed:articleTitle |
alpha-Neoendorphin-like immunoreactivity in medullary carcinoma of the thyroid.
|
pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|