Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1987-3-5
|
| pubmed:abstractText |
Recently, work in this laboratory has shown that changes in the 'dynamic' component of fluidity, lipid composition and phospholipid methylation activity of distal colonic brush-border membranes could be detected after administration of 1,2-dimethylhydrazine to rats of the Sherman strain for 5-15 weeks, i.e., before the development of colon cancer. The present experiments were therefore conducted to: determine whether similar 'premalignant' biochemical changes could be detected in basolateral membranes of Sherman rats treated with this agent; and clarify the relationship of these membrane changes to the malignant transformation process by examining the effect of 1,2-dimethylhydrazine on these biochemical parameters in colonic antipodal plasma membranes of rats of the Lobund-Wistar strain. This particular strain of rats has previously been shown to be total resistant to the induction of tumors by 1,2-dimethylhydrazine. The results of the present experiments demonstrate that similar biochemical alterations could not be detected in the colonic plasma membranes prepared from either strain of rat treated with 1,2-dimethylhydrazine. These data support the contention that the prior biochemical membrane alterations noted in brush-border membranes of 1,2-dimethylhydrazine-treated animals are, in fact, related to the malignant transformation process and, furthermore, are confined to the luminal surface of distal colonic epithelial cells.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1,2-Dimethylhydrazine,
http://linkedlifedata.com/resource/pubmed/chemical/Dimethylhydrazines,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Methylhydrazines,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipids
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0006-3002
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
26
|
| pubmed:volume |
896
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
311-7
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:3801474-1,2-Dimethylhydrazine,
pubmed-meshheading:3801474-Adenocarcinoma,
pubmed-meshheading:3801474-Animals,
pubmed-meshheading:3801474-Cell Membrane,
pubmed-meshheading:3801474-Colon,
pubmed-meshheading:3801474-Colonic Neoplasms,
pubmed-meshheading:3801474-Dimethylhydrazines,
pubmed-meshheading:3801474-Drug Resistance,
pubmed-meshheading:3801474-Immunity, Innate,
pubmed-meshheading:3801474-Male,
pubmed-meshheading:3801474-Membrane Fluidity,
pubmed-meshheading:3801474-Membrane Lipids,
pubmed-meshheading:3801474-Methylation,
pubmed-meshheading:3801474-Methylhydrazines,
pubmed-meshheading:3801474-Microvilli,
pubmed-meshheading:3801474-Phospholipids,
pubmed-meshheading:3801474-Rats,
pubmed-meshheading:3801474-Rats, Inbred Strains
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
1,2-Dimethylhydrazine-induced alterations in colonic plasma membrane fluidity: restriction to the luminal region.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|