Linked Life Data

3799518

Source:http://linkedlifedata.com/resource/pubmed/id/3799518

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1 Suppl
pubmed:dateCreated
1987-2-12
pubmed:abstractText
In postmenopausal women, obesity is positively related to the risk of both breast and endometrial cancer. Additionally, obesity is associated with increased estrogen production secondary to increased peripheral aromatization. In postmenopausal women, this effect is proportionately more significant because the ovaries no longer contribute to production of estrogen. Obesity also alters the further metabolism of estrogens, resulting in products that retain estrogenic potency. Consequently, the estrogen-sensitive tissues of obese women are exposed to more stimulation than those tissues in leaner women. It is possible that this increased estrogen exposure is responsible for the augmented risk of breast and endometrial cancer observed in obesity. Evidence is accumulating that dietary macronutrients can alter the metabolism and excretion of endogenous estrogen and androgen, providing a potential mechanism by which diet can modulate the risk of hormone-sensitive cancers.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0002-9165
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
283-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Obesity, diet, endogenous estrogens, and the risk of hormone-sensitive cancer.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.