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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1987-2-19
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pubmed:abstractText |
Evoked and spontaneous excitatory post-synaptic potentials (e.p.s.p.s) at the mossy fibre input to CA3 pyramidal neurones were recorded intracellularly in slices from the guinea-pig hippocampus. The effects of several amino acid antagonists on these responses were examined. L-2-amino-4-phosphonobutyrate (L-AP4), L-serine-O-phosphate (L-SOP), kynurenate, and N-(p-bromobenzoyl)piperazine-2,3-dicarboxylate (pBB-PzDA) reduced the amplitude of evoked mossy fibre e.p.s.p.s without affecting membrane potential or input resistance. Antagonism of mossy fibre spontaneous miniature e.p.s.p.s (m.e.p.s.p.s) by these compounds fell into two groups. L-AP4 and L-SOP applied at concentrations that blocked evoked e.p.s.p.s did not affect amplitude distributions of spontaneous m.e.p.s.p.s. Kynurenate and pBB-PzDA significantly affected the amplitude distributions and reduced the mean amplitude of spontaneous m.e.p.s.p.s. These results are consistent with a presynaptic site of action for L-AP4 and L-SOP and a post-synaptic site of action for kynurenate and pBB-PzDA as antagonists of e.p.s.p.s at the guinea-pig mossy fibre-CA3 pyramidal neurone synapse.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-227531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-2867215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-2981298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-2986039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-2986785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-3009733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-6098881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-6112965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-6126260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-6126848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-6130129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-6133585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-6134823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-6135181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-6136416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-6136553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-6137561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-6137788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-6142499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-6145492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-6145514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-6215086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-6264312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-6266585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-6287270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-6306230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-6311346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-6317423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-6318883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-6318908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-6332180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-6412962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3795109-7042024
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-3751
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
378
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
403-15
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3795109-Action Potentials,
pubmed-meshheading:3795109-Amino Acids,
pubmed-meshheading:3795109-Animals,
pubmed-meshheading:3795109-Evoked Potentials,
pubmed-meshheading:3795109-Guinea Pigs,
pubmed-meshheading:3795109-Hippocampus,
pubmed-meshheading:3795109-Nerve Fibers,
pubmed-meshheading:3795109-Neurons,
pubmed-meshheading:3795109-Neurons, Afferent,
pubmed-meshheading:3795109-Synapses
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pubmed:year |
1986
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pubmed:articleTitle |
Effects of excitatory amino acid antagonists on evoked and spontaneous excitatory potentials in guinea-pig hippocampus.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, Non-P.H.S.
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