Linked Life Data

3792621

Source:http://linkedlifedata.com/resource/pubmed/id/3792621

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1987-1-27
pubmed:abstractText
In the chick, sensory neurons grow to their segmentally appropriate target sites in the hindlimb from the outset during normal development. To elucidate the underlying mechanisms, we performed various manipulations of the neural tube, including the neural crest, or of the hindlimb, before axonal outgrowth and assessed the resulting sensory projections using retrograde and anterograde HRP labeling and electrophysiological techniques. Previous experiments had shown that motoneurons are specified to project to their appropriate target muscles prior to axon outgrowth and that they respond to cues in the limb in order to grow to those targets (C. Lance-Jones and L. Landmesser, 1980, J. Physiol. (London) 302, 559-602; C. Lance-Jones and L. Landmesser, 1981, Proc. R. Soc. London, B 214, 19-52). When several segments of neural tube and neural crest were deleted, sensory neurons in the remaining segments still projected along their correct pathways, as did motoneurons. In situations in which motoneurons grew to their correct targets from altered positions with respect to the limb (e.g., small neural tube reversals), sensory neurons also tended to project along the segmentally appropriate pathways both to skin and to muscle. In situations in which motoneurons were displaced greater distances from their normal point of entry into the limb and made wrong connections (e.g., large neural tube reversals, anterior-posterior limb reversals), sensory neurons also projected incorrectly. The patterns of sensory projections to muscles were, in each situation, generally similar to the motoneuron projections. These results are consistent with the possibility that sensory neurons, like motoneurons, are specified with respect to their peripheral connectivity. Alternatively, the results suggest that motoneurons may play a role in the process of pathway selection by sensory neurons.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0012-1606
pubmed:author
pubmed:issnType
Print
pubmed:volume
118
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
532-48
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
The development of sensory projection patterns in embryonic chick hindlimb under experimental conditions.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.